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KMID : 0606620090050010011
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Korean Journal of Fetal Medicine
2009 Volume.5 No. 1 p.11 ~ p.16
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Genotype distribution of factor V Leiden and prothrombin G20210A mutations in Korean women with hypertensive diseases in pregnancy
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Park Hyun-Soo
Kim Kun-Woo
Park Chan-Wook
Park Joong-Shin
Jun Jong-Kwan
Syn Hee-Chul
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Abstract
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Objectives: To evaluate genotype distribution of prothrombin gene G20210A mutation and factor V Leiden mutation in Korean women with hypertensive diseases in pregnancy.
Methods: One hundred and seventy-five pregnant women with hypertensive diseases in pregnancies were included in this study during the period of October 1998 and July 2001. Review of the medical records was done retrospectively. Venous blood was collected and DNA was extracted. Genotyping for factor V Leiden mutation and prothrombin gene G20210A mutation was done by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods.
Results: All subjects were homozygous for wild type allele. Factor V Leiden mutation and prothrombin gene
G20210A mutation were not found in any of the study population.
Conclusions: Factor V Leiden mutation and prothrombin gene G20210A mutation are unlikely to be associated with the hypertensive diseases in Korean women.
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KEYWORD
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Hypertensive diseases, Pregnancy, Factor V Leiden mutation, Prothrombin gene G20210A mutation
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